Hatice Savas, Venkatesh Murthy, Edward Ficaro, Jeffery Meden and James Corbett, Journal of Nuclear Medicine May 2013, 54 (supplement 2) 1687.
Description:
The objective of this study was to evaluate quantitative differences in background FDG uptake (liver and blood pool) and peak myocardial uptake in three protocols:
(1) high fat preparatory diet (HFPD)+heparin used to minimize uptake in normal myocardial tissue imaging inflammatory heart disease,
(2) glucose loading CLAMP in viability (VIAB) imaging, and
(3) fast (FAST) preparation for tumor imaging.
Clinical Relevance:
Quantitative myocardial and background FDG uptake varies significantly with disease state and metabolic preparation. In cardiac sarcoidosis and other inflammatory conditions, the HFPD+heparin protocol effectively reduces normal myocardial FDG uptake, improving visualization of active inflammation. Although myocardial uptake remained variable, background activity followed predictable trends by protocol, supporting standardized approaches for quantitative image interpretation and enhancing diagnostic reliability in PET assessment of myocardial inflammation and viability.
Partners in Research:
INVIA Medical Imaging Solutions and the University of Michigan collaborated on this research.
