EP Ficaro, JN Kritzman, JR Corbett.
University of Michigan, Ann Arbor, MI. Journal of Nuclear Medicine, 2000; 41(5):121P.
Description:
This study examined how body habitus and sample size influence the stability and diagnostic accuracy of normal perfusion databases used for quantitative myocardial perfusion SPECT analysis. The goal was to determine the minimum number of normal studies required to construct a reliable reference database without excluding patients based on body type.
Clinical Relevance:
Accurate normal databases are fundamental for quantitative SPECT perfusion interpretation. Databases built from fewer than 40 patients show variable diagnostic performance influenced by body habitus, whereas those constructed from 60 or more patients yield more consistent variance maps and stable diagnostic thresholds, improving the reliability of quantitative results.
Partners in Research:
INVIA Medical Imaging Solutions and the University of Michigan collaborated on this research.
