Moody, J.B., Hiller, K.M., Lee, B.C. et al. The utility of 82Rb PET for myocardial viability assessment: Comparison with perfusion-metabolism 82Rb-18F-FDG PET. J. Nucl. Cardiol. 26, 374–386 (2019).
Description:
This study looked into the relationship between 82Rb kinetic parameters and myocardial viability compared with conventional 82Rb and 18F-FDG perfusion-metabolism PET imaging.
Researchers reviewed dynamic 82Rb 3D PET data from 120 patients and 37 normal volunteers, estimating 82Rb kinetic parameters K1, k2, and the partition coefficient (KP) through compartmental modeling.
Clinical Relevance:
The study found that 82Rb kinetic parameters k2 and KP could significantly distinguish between scarred and hibernating myocardium segments, with KP showing high sensitivity and specificity. These results suggest that 82Rb kinetic parameters could serve as valuable tools in assessing myocardial viability and potentially predicting the benefits of revascularization in patients with dysfunctional myocardium. Further study is necessary to evaluate their clinical utility for predicting benefit after revascularization.
Partners in Research:
INVIA Medical Imaging Solutions and the University of Michigan collaborated on this research.
