Renaud, J.M., Poitrasson-Rivière, A., Hagio, T. et al. Myocardial flow reserve estimation with contemporary CZT-SPECT and 99mTc-tracers lacks precision for routine clinical application. J. Nucl. Cardiol. 29, 2078–2089 (2022).
Description:
Researchers investigated whether SPECT MFR precision is sufficient for clinical categorization of patients. Through a review of studies comparing SPECT MFR with PET (Positron Emission Tomography) MFR and invasive flow measurements, as well as a repeatability study, the imprecision of SPECT MFR measurements was determined. The imprecision values ranged from 0.556 to 0.878, leading to simulations that demonstrated poor classification accuracy for moderate MFR values but higher confidence for extreme MFR values.
Clinical Relevance:
Based on the measurement uncertainty, SPECT MFR should only be used selectively and cautiously in clinic practice until large-scale, blinded, diagnostic and prognostic clinical trials have been performed.
Partners in Research:
INVIA Medical Imaging Solutions and the University of Michigan collaborated on this research.
