Poitrasson-Rivière, A., Moody, J.B., Renaud, J.M. et al. Effect of iterations and time of flight on normal distributions of 82Rb PET relative perfusion and myocardial blood flow. J. Nucl. Cardiol. 29, 2612–2623 (2022).
Description:
This study evaluated the reconstruction parameters for dynamic 82Rb PET myocardial perfusion imaging to identify optimal conditions for accurate quantification of myocardial blood flow (MBF).
Rest and stress dynamic series from 59 participants were reconstructed with and without time-of-flight (TOF) information across varying iterations. The study aimed to determine the effects of these parameters on relative perfusion and MBF polar maps and to identify optimal reconstruction algorithms.
Clinical Relevance:
The findings suggest that TOF reconstructions provide faster convergence and more uniform relative perfusion polar maps compared to non-TOF reconstructions. However, TOF reconstructions showed a more heterogeneous stress MBF distribution, warranting further investigation into potential spillover effects.
Partners in Research:
INVIA Medical Imaging Solutions and the University of Michigan collaborated on this research.
